Carrie McLean (Sharoff), PhD, teaches exercise physiology for the MGH Institute Online Prerequisites for the Health Professions.
Dr. McLean grew up in New York and obtained her undergraduate degree in Political Science from Binghamton University. She next moved on to the University of Massachusetts, Amherst where she completed her masters and PhD in Kinesiology.
Dr. McLean's area of expertise is Energy Metabolism and her main areas of interest are metabolism and understanding how exercise can be used to treat and prevent type 2 diabetes. After completing her PhD, Dr. McLean was a postdoctoral fellow at the Arizona State University in the Center for Metabolic Biology/Mayo Clinic where she worked on studies that utilized proteomics to understand how exercise alters insulin signaling proteins.
- BA, Political Science (with high honors), Binghamton University, Binghamton, Ny
- MS, Exercise Science, concentration in Enegry Metabolism, University of Massachusetts, Amherst, MA
- PhD, Kinesiology, concentration in Exercise Energy Metabolism, University of Massachusetts, Amherst, MA
Mielke C, Lefort N, McLean CG, Cordova JM, Langlais PR, Bordner AJ, Te JA, Ozkan SB, Willis WT, Mandarino LJ. Adenine nucleotide translocase is acetylated in vivo in human muscle: modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation. Biochemistry. 2014 Jun 17;53(23):3817-29. Doi: 10.102/bi401651e. Epub 2014 Jun 9.
Sharoff CG*, Hussey SE* , Garnham A, Zhengping Y, Bowen B, Mandarino LJ, Hargreaves M. Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes. Med Sci Sports Exerc. 2013 Jun;45(6):1069-76. Doi: 10.1249/MSS.0b013e3182814917.
Sharoff CG, Hagobian TA, Malin SK, Chipkin SR, Yu H, Hirshman MF, Goodyear LJ, Braun, B. Combining short-term metformin treatment and acute exercise does not increase insulin action in insulin-resistant individuals. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E815-23. Epub 2010 Jan 13.
Malin S, Stephens BR, Sharoff CG, Chipkin SR, Braun B. Metformin’s effect on exercise and postexercise substrate oxidation. International Journal of Sport Nutrition and Exercise Metabolism. 2010 Feb;20(1):63-71. EPub.
Hagobian TA, Sharoff CG, Silva E, Wade G, Chipkin SR, Braun B. Effects of exercise on energy regulating hormones in men and women. Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R233-42. Epub 2008 Dec 10.